In the early 1990s, her rebelliousness played itself out on screen and in print.
Barrymore forged an image as a manipulative teenage seductress, beginning with Poison Ivy (1992), which was a box office failure, but was popular on video and cable.
Barrymore grew up on Poinsetta Place in West Hollywood until the age of 7, when she moved to Sherman Oaks.
Barrymore starred in Far from Home (1989), as a teenager who gets stranded with her father in the small town in a remote part of the desert.
The film went largely unnoticed by audiences and received negative reviews from critics, who dismissed the sexual portrayal of her role.
She was in rehab at the age of fourteen, put her back in rehab, followed by a three-month stay with singer David Crosby (of rock group Crosby, Stills, Nash & Young) and his wife.
The stay was precipitated, Crosby said, because she "needed to be around some people that were committed to sobriety." Barrymore later described this period of her life in her autobiography, Little Girl Lost.
She starred in the 1985 anthology horror film Cat's Eye, written again by Stephen King.
The film received positive reviews and Barrymore was nominated for a Young Artist Award for Best Leading Young Actress.
In 1995, she and Nancy Juvonen formed a joint production company, Flower Films, and went on to produce several films in which Barrymore also starred, such as Never Been Kissed (1999), Charlie's Angels (2000), Donnie Darko (2001), Fever Pitch (2005), Music and Lyrics (2007), and her directorial debut Whip It! Barrymore won a Screen Actors Guild Award and a Golden Globe Award for her performance in the HBO drama film Grey Gardens (2009).
Since 2017, she has starred in the Netflix television series Santa Clarita Diet.
She moved back to West Hollywood, upon becoming emancipated at 14.
In the wake of her sudden stardom, Barrymore endured a notoriously troubled childhood.
Both thrillers were panned by critics and failed to find an audience.